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Literature summary for 2.7.11.22 extracted from

  • Ishikawa, M.; Murata, T.; Sato, Y.; Nishiyama, T.; Hiwatashi, Y.; Imai, A.; Kimura, M.; Sugimoto, N.; Akita, A.; Oguri, Y.; Friedman, W.E.; Hasebe, M.; Kubo, M.
    Physcomitrella cyclin-dependent kinase A links cell cycle reactivation to other cellular changes during reprogramming of leaf cells (2011), Plant Cell, 23, 2924-2938.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
cyclin B activates CDKA Physcomitrium patens
additional information poor activation of CDKA with cyclin D Physcomitrium patens

Cloned(Commentary)

Cloned (Comment) Organism
expression of tagged isozyme CDKA;1 as inducible enzyme in wild-type Physcomitrella patens Physcomitrium patens

Organism

Organism UniProt Comment Textmining
Physcomitrium patens
-
 isozymes CDKA;1, and CDKA;2
-
Physcomitrium patens Gransden-2004
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 isozymes CDKA;1, and CDKA;2
-

Source Tissue

Source Tissue Comment Organism Textmining
gametophore gametophore leaf cell Physcomitrium patens
-
leaf
-
 Physcomitrium patens
-

Synonyms

Synonyms Comment Organism
CDKA
-
 Physcomitrium patens
cyclin-dependent kinase A
-
 Physcomitrium patens

General Information

General Information Comment Organism
malfunction treatment of leaf cells with a CDK inhibitor or induction of dominant-negative CDKA1 protein inhibits not only cell cycle progression but also tip growth and protonemal gene expression Physcomitrium patens
metabolism activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Cell cycle progression is not required for acquisition of protonema cell-type characteristics Physcomitrium patens
physiological function the activity of cyclin-dependent kinase A links cell cycle reactivation and the acquisition of new cell-type characteristics during reprogramming in the moss Physcomitrella patens, overview. Leaf cells facing the cut undergo CDK activation along with induction of a D-type cyclin, tip growth, and transcriptional activation of protonema-specific genes, CDKA regulates protonema-specific genes and tip growth, as well as cell cycle progression and other cellular changes in parallel. But iozymes CDKA;1 and CDKA;2 are expressed before cutting and activated afterwards Physcomitrium patens