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Literature summary for 2.7.11.22 extracted from

  • Chan, K.C.; Ho, H.H.; Peng, C.H.; Lan, K.P.; Lin, M.C.; Chen, H.M.; Wang, C.J.
    Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase (2010), J. Agric. Food Chem., 58, 2536-2542.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A7r5 cell
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 Rattus norvegicus
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vascular smooth muscle cell
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
CDK
-
 Rattus norvegicus
CDK2
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 Rattus norvegicus
CDK4
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
cyclin
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the protein levels of cyclin A, cyclin E, and CDK2 are decreased significantly (up to 0.53, 0.49, and 0.36fold as compared to the control group, respectively) in a dose-dependent manner after treatment with mulberry leaf extract (0.5-2.0 mg/ml) for 24 h, and in a time-dependent manner (up to 0.9, 0.5, and 0.74fold as compared to the control group, respectively) after treatment with mulberry leaf extract (1.5 mg/ml) down
Rattus norvegicus the protein levels of cyclin D1 and CDK4 but not cyclin D3 are increased significantly (up to 1.8 and 1.3fold as compared to the control group, respectively) in a dose-dependent manner after treatment with mulberry leaf extract (0.5-2.0 mg/ml for 24 h) and increase significantly (up to 1.35 and 1.75fold as compared to the control group, respectively) in a time-dependent manner after treatment with mulberry leaf extract (1.5 mg/ml) up