Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CDK-activating kinase | the CDK-activating kinase (having three subunits, CDK7, cyclin H, and MAT1) plays a critical role in regulating cell cycle by mediating the activating phosphorylation of CDK1, CDK2, CDK4, and CDK6 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BS-181 | only inhibits CDK2 at concentrations lower than 1 mM, with CDK2 being inhibited 35fold less potently than CDK7 | Homo sapiens | |
roscovitine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II | - |
Homo sapiens | ADP + phosphorylated RNA polymerase II | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk1 | - |
Homo sapiens |
CDK2 | - |
Homo sapiens |
CDK4 | - |
Homo sapiens |
Cdk5 | - |
Homo sapiens |
cdk6 | - |
Homo sapiens |
cdk7 | - |
Homo sapiens |
CDK9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cyclin D1 | cofactor of CDK4 | Homo sapiens | |
cyclin E | cofactor of CDK2 | Homo sapiens | |
cyclin H | cofactor of CDK7 | Homo sapiens | |
cyclin T | cofactor of CDK9 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000021 | - |
CDK7 | Homo sapiens | BS-181 | |
0.0001 | - |
CDK2 | Homo sapiens | roscovitine | |
0.00024 | - |
CDK5 | Homo sapiens | roscovitine | |
0.00051 | - |
CDK7 | Homo sapiens | roscovitine | |
0.00088 | - |
CDK2 | Homo sapiens | BS-181 | |
0.0012 | - |
CDK9 | Homo sapiens | roscovitine | |
0.0018 | - |
CDK1 | Homo sapiens | roscovitine | |
0.003 | - |
CDK5 | Homo sapiens | BS-181 | |
0.0042 | - |
CDK9 | Homo sapiens | BS-181 | |
0.0081 | - |
CDK1 | Homo sapiens | BS-181 | |
0.0153 | - |
CDK4 | Homo sapiens | roscovitine | |
0.028 | - |
CDK6 | Homo sapiens | roscovitine | |
0.033 | - |
CDK4 | Homo sapiens | BS-181 | |
0.047 | - |
CDK6 | Homo sapiens | BS-181 |