Literature summary for 2.7.11.22 extracted from

Wang, S.; Fischer, P.M.
Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology (2008), Trends Pharmacol. Sci., 29, 302-313.

Search for more literature for 2.7.11.22

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	cardiac CDK9 is initially activated by hypertrophic stimuli	Homo sapiens

Application

Application	Comment	Organism
medicine	CDK9 is a key transcriptional regulator and potential drug target in oncology, virology and cardiology	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
anilinopyrimidine 32	-	Homo sapiens
arylazopyrazole 31b	-	Homo sapiens
deoxyvariolin B	-	Homo sapiens
DRB	-	Homo sapiens
flavopiridol	alvocidib	Homo sapiens
indirubin 3'-monoxime	-	Homo sapiens
meridianin A	-	Homo sapiens
meridianin G	-	Homo sapiens
meriolin 1	-	Homo sapiens
meriolin 2	-	Homo sapiens
meriolin 3	-	Homo sapiens
P276-00	-	Homo sapiens
R547	-	Homo sapiens
RBG-286147	-	Homo sapiens
roscovitine	seliciclib	Homo sapiens
SNS-032	-	Homo sapiens
variolin B	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50750	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + RNA polymerase II	CDK9 phosphorylates the carboxy-terminal domain of the largest subunit (RPB1) of RNA polymerase II	Homo sapiens	ADP + phosphorylated RNA polymerase II	-	?

Synonyms

Synonyms	Comment	Organism
CDK9	CDK9 is a cdc2-like Ser/Thr kinase whose complexes with T- and K-type cyclins constitute the basal transcription factor P-TEFb	Homo sapiens
cyclin-dependent kinase 9	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
cyclin K	-	Homo sapiens
cyclin T	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)