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Literature summary for 2.7.11.22 extracted from

  • Hume, A.J.; Finkel, J.S.; Kamil, J.P.; Coen, D.M.; Culbertson, M.R.; Kalejta, R.F.
    Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function (2008), Science, 320, 797-799.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K355M catalytically inactive Human betaherpesvirus 5
K355Q mutant fails to induce phosphorylation of retinoblastoma protein Human betaherpesvirus 5

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by the CDK inhibitor p21 Human betaherpesvirus 5

Organism

Organism UniProt Comment Textmining
Human betaherpesvirus 5
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + retinoblastoma protein
-
Human betaherpesvirus 5 ADP + phosphorylated retinoblastoma protein
-
?

Synonyms

Synonyms Comment Organism
UL97 protein has activities similar to cellular cyclin-cyclin-dependent kinase complexes Human betaherpesvirus 5