Literature summary for 2.7.11.22 extracted from

Chen, H.; Van Duyne, R.; Zhang, N.; Kashanchi, F.; Zeng, C.
A novel binding pocket of cyclin-dependent kinase 2 (2008), Proteins, 74, 122-132.

Search for more literature for 2.7.11.22

Protein Variants

Protein Variants	Comment	Organism
K178A	the mutant shows reduced affinity for inhibitory peptide TAALS	Homo sapiens
Y180A	the mutant shows reduced affinity for inhibitory peptide TAALS	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
FAALS	five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex	Homo sapiens
LAALS	five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex	Homo sapiens
TAACS	five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex	Homo sapiens
TAALD	five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex	Homo sapiens
TAALE	five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex	Homo sapiens
TAALS	disrupts the cdk2/cyclin E complex	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P24941	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C-81 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + RNA polymerase II	-	Homo sapiens	ADP + phosphorylated RNA polymerase II	-	?

Synonyms

Synonyms	Comment	Organism
CDK2	-	Homo sapiens
cyclin-dependent kinase 2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
cyclin E	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00426	-	-	Homo sapiens	LAALS
0.0261	-	-	Homo sapiens	TAALS

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)