Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p25 | physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262, p25 with a much stronger effect than p35 on suppression of glucocorticoid receptor transcriptional activity | Rattus norvegicus | |
p35 | physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262 | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | CDK5 exerts some of its biologic activities in neuronal cells through the glucocorticoid receptor, dynamically modulating glucocorticoid receptor transcriptional activity in a target promoter dependent fashion | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
CDK5, p35, p25 and glucocorticoid receptor expressed in HCT116 cells and COS-7 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
D144N | defective in its kinase activity, weakly increases glucocorticoid receptor-induced transcriptional activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
roscovitine | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glucocorticoid receptor | CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA | Rattus norvegicus | ADP + dephosphorylated glucocorticoid receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Rattus norvegicus |
cyclin-dependent kinase 5 | - |
Rattus norvegicus |