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Literature summary for 2.7.11.22 extracted from

  • Kino, T.; Ichijo, T.; Amin, N.D.; Kesavapany, S.; Wang, Y.; Kim, N.; Rao, S.; Player, A.; Zheng, Y.L.; Garabedian, M.J.; Kawasaki, E.; Pant, H.C.; Chrousos, G.P.
    Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress (2007), Mol. Endocrinol., 21, 1552-1568.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
p25 physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262, p25 with a much stronger effect than p35 on suppression of glucocorticoid receptor transcriptional activity Rattus norvegicus
p35 physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262 Rattus norvegicus

Application

Application Comment Organism
additional information CDK5 exerts some of its biologic activities in neuronal cells through the glucocorticoid receptor, dynamically modulating glucocorticoid receptor transcriptional activity in a target promoter dependent fashion Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
CDK5, p35, p25 and glucocorticoid receptor expressed in HCT116 cells and COS-7 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D144N defective in its kinase activity, weakly increases glucocorticoid receptor-induced transcriptional activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
roscovitine
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glucocorticoid receptor CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA Rattus norvegicus ADP + dephosphorylated glucocorticoid receptor
-
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Synonyms

Synonyms Comment Organism
Cdk5
-
Rattus norvegicus
cyclin-dependent kinase 5
-
Rattus norvegicus