Literature summary for 2.7.11.22 extracted from

Chen, Y.; Jirage, D.; Caridha, D.; Kathcart, A.K.; Cortes, E.A.; Dennull, R.A.; Geyer, J.A.; Prigge, S.T.; Waters, N.C.
Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase (2006), Mol. Biochem. Parasitol., 149, 48-57.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cyclin	stimulates, does not affect autophosphorylation	Plasmodium falciparum
PfMAT1	stimulates Pfmrk kinase activity in a cyclin-dependent manner, does not affect autophosphorylation	Plasmodium falciparum

Protein Variants

Protein Variants	Comment	Organism
F143L	4-10fold increase in Pfmrk activity, significant kinase activity in the absence of either cyclin or PfMAT1	Plasmodium falciparum
S138K	4-10fold increase in Pfmrk activity, significant kinase activity in the absence of either cyclin or PfMAT1	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	autophosphorylation of Pfmrk, can not phosphorylate PfPK5	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
CDK	-	Plasmodium falciparum
cyclin-dependent protein kinase	-	Plasmodium falciparum
Pfmrk	-	Plasmodium falciparum

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Release 2023.1 (January 2023)