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Literature summary for 2.7.11.22 extracted from
- Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation (2007), J. Biol. Chem., 282, 12842-12850.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p25 | - |
Homo sapiens | |
| p25 | - |
Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Cdk5 is a regulator of the parkin ubiquitin-ligase activity and modulates its ability to accumulate into and modify inclusions. Phosphorylation by Cdk5 may contribute to the accumulation of toxic parkin substrates and decrease the ability of dopaminergic cells to cope with toxic insults in Parkinson disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| co-transfection of HEK 293 cells with myc-Cdk5, His-p25, and either wild-type or parkin mutants | Homo sapiens |
| expressed in HEK-293 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Olomoucine | decreases by ca. 30% the phosphorylation of parkin | Homo sapiens |  |
| roscovitine | decreases by ca. 30% the phosphorylation of parkin | Homo sapiens | |
| roscovitine | - |
Rattus norvegicus | |
| siRNA | decreases by ca. 35% the phosphorylation of parkin | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + parkin | Homo sapiens | Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin, parkin S131A mutant has 40% lower phosphorylation levels in vivo than wild-type parkin | ADP + phosphorylated parkin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus | Q03114 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| HEK-293 cell | - |
Homo sapiens | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + parkin | - |
Rattus norvegicus | ADP + phosphorylated parkin | - |
? | |
| ATP + parkin | Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin, parkin S131A mutant has 40% lower phosphorylation levels in vivo than wild-type parkin | Homo sapiens | ADP + phosphorylated parkin | - |
? | |
| ATP + parkin | Ser-131 located at the linker region of parkin is the major Cdk5 phosphorylation site, phosphorylation by Cdk5 decreases the auto-ubiquitylation of parkin | Homo sapiens | ADP + phosphorylated parkin | - |
? | |
| ATP + parkin | parkin has four putative Cdk5 phosphorylation sites according to the motif (S/T)PX(K/R) | Rattus norvegicus | ADP + phosphorylated parkin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Homo sapiens |
| Cdk5 | - |
Rattus norvegicus |
| cyclin-dependent kinase 5 | - |
Homo sapiens |
| cyclin-dependent kinase 5 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cyclin | - |
Rattus norvegicus |
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