Literature summary for 2.7.11.22 extracted from

Baatout, S.; Mueller, W.; Michaux, A.; Buset, J.; Schoonjans, W.; Jacquet, P.
Histone H1 and cdk1 kinase activities in early embryos of four mouse strains after X-irradiation (2007), In Vivo, 21, 571-582.

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Application

Application	Comment	Organism
additional information	cell-cycle effects in early embryos under normal conditions and after irridation are paralleled by changes in the activity of the central cell-cycle driving enzyme complex, the cdk1/cyclin B1 complex	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	after irridation of one- or two-cell embryos the cdk1/cyclin B1 complex is blocked	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	radiation-sensitive strain BALB/c and the radiation-resistant strain C57BL	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	inactive and phosphorylated form of cdk1 present in G2 arrested one-cell embryos, while the active and dephosphorylated form of cdk1 present in dividing control and irradiated one-cell embryos	Mus musculus	-
oocyte	in MII oocytes only the dephosphorylated active form of cdk1 present, just after fertilization, the amount of the dephosphorylated form decreases, whereas that of the phosphorylated form increases	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cdk1 kinase	-	Mus musculus
cdk1/cyclin B1 complex	-	Mus musculus

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Release 2023.1 (January 2023)