Literature summary for 2.7.11.22 extracted from

Strock, C.J.; Park, J.I.; Nakakura, E.K.; Bova, G.S.; Isaacs, J.T.; Ball, D.W.; Nelkin, B.D.
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells (2006), Cancer Res., 66, 7509-7515.

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Activating Compound

Activating Compound	Comment	Organism	Structure
p35	-	Homo sapiens

Application

Application	Comment	Organism
medicine	plays an important role in prostate cancer motility and metastasis, is important for spontaneous metastasis in vivo	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
dominant-negative CDK5 mutant subcloned into a bidirectional vector expressing GFP in a Tet-Off system and expressed in AT6.3 cells, mice subcutaneous xenografts of AT6.3 cells expressing the dominant-negative CDK5 mutant	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D144N	dominant-negative CDK5 mutant, results in a loss of motility of the cells through effects on the cytoskeleton, which correlates with dramatically lower invasive potential, leads to 79% reduction in the number of lung metastases per milligram of primary xenograft tumors	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
roscovitine	blocks the motility of prostate cancer cells in a wound healing assay	Homo sapiens
siRNA	blocks the motility of prostate cancer cells in a wound healing assay	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DU-145 cell	CDK5 together with p35	Homo sapiens	-
LNCaP cell	CDK5 together with p35	Homo sapiens	-
additional information	CDK5 together with p35 present in AT6.3 cells, AT3.1 cells, MatLu cells and MatLyLu cells	Homo sapiens	-
PC-3 cell	CDK5 together with p35	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + PKTPKKAKKL	-	Homo sapiens	ADP + PKpTPKKAKKL	-	?

Synonyms

Synonyms	Comment	Organism
Cdk5	-	Homo sapiens
cyclin-dependent kinase 5	-	Homo sapiens

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Release 2023.1 (January 2023)