Literature summary for 2.7.11.22 extracted from

Yang, H.S.; Hinds, P.W.
Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells (2006), Cancer Res., 66, 2708-2715.

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Application

Application	Comment	Organism
medicine	role for cdk5 and Rho-GDI in senescence, cdk5-dependent decrease in ezrin-bound Rho-GDI can lead to increased Rho-GDI/Rac1 complexes and consequent Rac1 inhibition	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
shRNA	cdk5 shRNA is able to efficiently inhibit the expression of endogenous cdk5	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SAOS-2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + ezrin	phosphorylation by cdk5 at Thr235 in the NH2-terminal region and consequent dissociation of Rho GDP dissociation inhibitor from an ezrin/Rho-GDI complex	Homo sapiens	ADP + phosphorylated ezrin	-	?

Synonyms

Synonyms	Comment	Organism
Cdk5	-	Homo sapiens
cyclin-dependent kinase 5	-	Homo sapiens

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Release 2023.1 (January 2023)