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Literature summary for 2.7.11.22 extracted from

  • Watanabe, N.; Arai, H.; Iwasaki, J.i.; Shiina, M.; Ogata, K.; Hunter, T.; Osada, H.
    Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic wee1 via multiple pathways (2005), Proc. Natl. Acad. Sci. USA, 102, 11663-11668.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Inhibitors

Inhibitors Comment Organism Structure
additional information CDK is inhibited by phosphorylation through somatic Wee1A in M phase Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Wee1A Homo sapiens phosphorylation at S123, S53, and S121 promotes binding of Wee1A by beta-TrCP, the beta-transducin repeat-containing protein, which is the substrate recognition component of the ubiquitin ligase, leading to proteasomal degradation of Wee1A, overview ADP + phosphorylated Wee1A
-
 ?
additional information Homo sapiens the polo-kinase 1, EC 2.7.11.21, also phosphorylates Wee1A at S53 and S123, casein kinase II, EC 2.7.11.1, also phosphorylates Wee1A at S121 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CDK is inhibited by phosphorylation through somatic Wee1A in M phase Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Wee1A phosphorylation at S123, S53, and S121 promotes binding of Wee1A by beta-TrCP, the beta-transducin repeat-containing protein, which is the substrate recognition component of the ubiquitin ligase, leading to proteasomal degradation of Wee1A, overview Homo sapiens ADP + phosphorylated Wee1A
-
 ?
ATP + Wee1A phosphorylation at S123, S53, and S121 Homo sapiens ADP + phosphorylated Wee1A
-
 ?
additional information the polo-kinase 1, EC 2.7.11.21, also phosphorylates Wee1A at S53 and S123, casein kinase II, EC 2.7.11.1, also phosphorylates Wee1A at S121 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin regulatory subunit of the CDK Homo sapiens