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Literature summary for 2.7.11.22 extracted from

  • Boudolf, V.; Vlieghe, K.; Beemster, G.T.; Magyar, Z.; Torres Acosta, J.A.; Maes, S.; Van Der Schueren, E.; Inze, D.; De Veylder, L.
    The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis (2004), Plant Cell, 16, 2683-2692.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene CDKB1,1 transcription is controlled by the E2F pathway with transcription factor E2Fa-DPa binding to the CDKB1,1 promoter, thus there is crosstalk between the G1-S and G2-M transition points, promoter analysis Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic plants expressing a negative dominant mutant of CDKB1,1 leading to stimulation to exit the mitosis, and of plants overexpressing the transcription factor E2Fa-DPa, these plants show two different cell-specific phenotypes: some divide ectopically and others are stimulated to endocycle, overexpression of the negative dominant CDKB1,1 mutant increases the endoreduplication phenotype, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana plant-specific cyclin-dependent kinase CDKB1,1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis thaliana, CDKB1,1 is required to inhibit the endocycle and promote the ectopic cell divisions triggered by E2Fa-DPa, regulation model ?
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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 gene CDKB1,1
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Source Tissue

Source Tissue Comment Organism Textmining
leaf CDKB1,1 is expressed only during mitotic phase of the leaf development, mutant leaves overexpressing CDKB1,1 dominant negative mutant show half the number of epidermal cells at maturity and increased temperature compared to wild-type leaves Arabidopsis thaliana
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information plant-specific cyclin-dependent kinase CDKB1,1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis thaliana, CDKB1,1 is required to inhibit the endocycle and promote the ectopic cell divisions triggered by E2Fa-DPa, regulation model Arabidopsis thaliana ?
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 ?

Synonyms

Synonyms Comment Organism
CDKB1,1
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 Arabidopsis thaliana