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Literature summary for 2.7.11.22 extracted from

  • Pic-Taylor, A.; Darieva, Z.; Morgan, B.A.; Sharrocks, A.D.
    Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p (2004), Mol. Cell. Biol., 24, 10036-10046.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Clbp1-Clbp6 cyclins, possible regulatory subunits of Cdc28p, each influencing the enzyme activity in a distinct way, overview Saccharomyces cerevisiae
Mcm1p regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation Saccharomyces cerevisiae
Ndd1p regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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Saccharomyces cerevisiae 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Fkh2p Saccharomyces cerevisiae phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview ADP + phosphorylated Fkh2p
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Fkh2p phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview Saccharomyces cerevisiae ADP + phosphorylated Fkh2p
-
?
ATP + Fkh2p forkhead transcription factor Fkh2p, C-terminally phosphorylation of Fkh2p promotes interaction with the activator Ndd1p, which becomes also phosphorylated, activity with Fkh2p mutants, overview Saccharomyces cerevisiae ADP + phosphorylated Fkh2p
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?

Subunits

Subunits Comment Organism
More complex formation of the active enzyme, coactivators and substrate, overview Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Cdc28p-Chlp kinase
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Saccharomyces cerevisiae
Mcm1p
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Saccharomyces cerevisiae

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 37 in vivo Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Saccharomyces cerevisiae