Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Clbp1-Clbp6 | cyclins, possible regulatory subunits of Cdc28p, each influencing the enzyme activity in a distinct way, overview | Saccharomyces cerevisiae | |
Mcm1p | regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation | Saccharomyces cerevisiae | |
Ndd1p | regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Fkh2p | Saccharomyces cerevisiae | phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview | ADP + phosphorylated Fkh2p | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Fkh2p | phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview | Saccharomyces cerevisiae | ADP + phosphorylated Fkh2p | - |
? | |
ATP + Fkh2p | forkhead transcription factor Fkh2p, C-terminally phosphorylation of Fkh2p promotes interaction with the activator Ndd1p, which becomes also phosphorylated, activity with Fkh2p mutants, overview | Saccharomyces cerevisiae | ADP + phosphorylated Fkh2p | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | complex formation of the active enzyme, coactivators and substrate, overview | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Cdc28p-Chlp kinase | - |
Saccharomyces cerevisiae |
Mcm1p | - |
Saccharomyces cerevisiae |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | 37 | in vivo | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |