Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.22 extracted from

  • Sanchez, V.; McElroy, A.K.; Spector, D.H.
    Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus (2003), J. Virol., 77, 13214-13224.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information activation mechanism and pathway of Cdk1/cyclin B, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Myt1 Cdk1 inhibitor Homo sapiens
Wee1 Cdk1 inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol determination of subcellular localization of Cdk1/cyclin B in HCMV-infected cells Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Cdk1/cyclin B is induced in cells with dysregulated cell cycle, e.g. after infection with the human cytomegalovirus, regulation mechanisms, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Cdk1 is inhibited by phosphorylation at Thr15, removal of the phosphates by the Cdc25 phosphatase reactivates the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cells infected with the human cytomegalovirus HCMV Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cdk1/cyclin B is induced in cells with dysregulated cell cycle, e.g. after infection with the human cytomegalovirus, regulation mechanisms, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More regulatory subunit cyclin B and catalytic subunit Cdk1 Homo sapiens

Synonyms

Synonyms Comment Organism
Cdk1
-
 Homo sapiens
Cdk1/cyclin B1 kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin B regulatory subunit cyclin B and catalytic subunit Cdk1, HCMV-infection leads to accumulation of active cyclin B in cells due to increased synthesis and reduced degradation Homo sapiens