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Literature summary for 2.7.11.22 extracted from

  • Vax, V.V.; Bibi, R.; Diaz-Cano, S.; Gueorguiev, M.; Kola, B.; Borboli, N.; Bressac-de Paillerets, B.; Walker, G.J.; Dedov, II; Grossman, A.B.; Korbonits, M.
    Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours (2003), J. Endocrinol., 178, 301-310.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
CDK4, DNA and amino acid sequence determinations in pituitary adenomas, insulinomas, or Leydig cell tumours Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genetic analysis of diverse human cancers, overview Homo sapiens
R24C naturally occurring activating point mutations R24C and R24H in CDK4 are not seen in sporadic pituitary adenomas, insulinomas, or Leydig cell tumours, but in melanomas, overview Homo sapiens
R24H naturally occurring activating point mutations R24C and R24H in CDK4 are not seen in sporadic pituitary adenomas, insulinomas, or Leydig cell tumours, but in melanomas, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
p16 i.e. p16INK4, inhibits CDK4, not CDK2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + retinoblastoma protein Homo sapiens phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase ADP + phosphorylated retinoblastoma protein
-
?
additional information Homo sapiens CDK4 governs cell cycle progression through the G1 phase, CDK2 is involved in all cell cycle phases, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
insulinoma cell
-
Homo sapiens
-
Leydig cell tumor cell
-
Homo sapiens
-
melanoma cell
-
Homo sapiens
-
pituitary adenoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + retinoblastoma protein phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase Homo sapiens ADP + phosphorylated retinoblastoma protein
-
?
ATP + retinoblastoma protein i.e. Rb protein, phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites Homo sapiens ADP + phosphorylated retinoblastoma protein
-
?
additional information CDK4 governs cell cycle progression through the G1 phase, CDK2 is involved in all cell cycle phases, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CDK2
-
Homo sapiens
CDK4
-
Homo sapiens
cyclin-dependent kinase 2
-
Homo sapiens
cyclin-dependent kinase 4
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
cyclin A is required as regulatory subunit of CDK2 in cell cycle S, M, and G1 phases Homo sapiens
cyclin B is required as regulatory subunit of CDK2 in cell cycle G2 and M phases Homo sapiens
cyclin D is required as regulatory subunit of CDK4 Homo sapiens
cyclin E is required as regulatory subunit of CDK2 in cell cycle G1 phase Homo sapiens