Cloned (Comment) | Organism |
---|---|
CDK4, DNA and amino acid sequence determinations in pituitary adenomas, insulinomas, or Leydig cell tumours | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic analysis of diverse human cancers, overview | Homo sapiens |
R24C | naturally occurring activating point mutations R24C and R24H in CDK4 are not seen in sporadic pituitary adenomas, insulinomas, or Leydig cell tumours, but in melanomas, overview | Homo sapiens |
R24H | naturally occurring activating point mutations R24C and R24H in CDK4 are not seen in sporadic pituitary adenomas, insulinomas, or Leydig cell tumours, but in melanomas, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p16 | i.e. p16INK4, inhibits CDK4, not CDK2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + retinoblastoma protein | Homo sapiens | phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase | ADP + phosphorylated retinoblastoma protein | - |
? | |
additional information | Homo sapiens | CDK4 governs cell cycle progression through the G1 phase, CDK2 is involved in all cell cycle phases, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
insulinoma cell | - |
Homo sapiens | - |
Leydig cell tumor cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
pituitary adenoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + retinoblastoma protein | phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites in the cell cycle G1 phase | Homo sapiens | ADP + phosphorylated retinoblastoma protein | - |
? | |
ATP + retinoblastoma protein | i.e. Rb protein, phosphorylation by CDK4/cyclin D at one site, or by CDK2/cyclin E or A at multiple sites | Homo sapiens | ADP + phosphorylated retinoblastoma protein | - |
? | |
additional information | CDK4 governs cell cycle progression through the G1 phase, CDK2 is involved in all cell cycle phases, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK2 | - |
Homo sapiens |
CDK4 | - |
Homo sapiens |
cyclin-dependent kinase 2 | - |
Homo sapiens |
cyclin-dependent kinase 4 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cyclin A | is required as regulatory subunit of CDK2 in cell cycle S, M, and G1 phases | Homo sapiens | |
cyclin B | is required as regulatory subunit of CDK2 in cell cycle G2 and M phases | Homo sapiens | |
cyclin D | is required as regulatory subunit of CDK4 | Homo sapiens | |
cyclin E | is required as regulatory subunit of CDK2 in cell cycle G1 phase | Homo sapiens |