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Literature summary for 2.7.11.22 extracted from
- Varicella-Zoster Virus IE63 Protein Phosphorylation by Roscovitine-sensitive Cyclin-dependent Kinases Modulates Its Cellular Localization and Activity (2005), J. Biol. Chem., 280, 29135-29143.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDK1 inhibitor III | i.e. ethyl(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate, inhibition of IE63 protein phosphorylation at Ser224 leads to exclusive localization of IE63 protein in the host nucleus | Chlorocebus aethiops |  |
| roscovitine | inhibition of IE63 protein phosphorylation at Ser224 leads to exclusive localization of IE63 protein in the host nucleus | Chlorocebus aethiops | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Chlorocebus aethiops | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Chlorocebus aethiops | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Varicella-Zoster virus IE63 protein | Chlorocebus aethiops | phosphorylation at Ser224 by CDK1 in vivo is required for correct localization of the virus protein, e.g. in the host cytoplasm during latency, S224A mutation leads to inhibition of phosphorylation and exclusive localization of IE63 protein in the nucleus | ADP + phosphorylated Varicella-Zoster virus IE63 protein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlorocebus aethiops | - |
African green monkey | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Vero cell | - |
Chlorocebus aethiops | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | commercial substrate | Chlorocebus aethiops | ADP + phosphorylated histone H1 | - |
? | |
| ATP + Varicella-Zoster virus IE63 protein | phosphorylation at Ser224 by CDK1 in vivo is required for correct localization of the virus protein, e.g. in the host cytoplasm during latency, S224A mutation leads to inhibition of phosphorylation and exclusive localization of IE63 protein in the nucleus | Chlorocebus aethiops | ADP + phosphorylated Varicella-Zoster virus IE63 protein | - |
? | |
| ATP + Varicella-Zoster virus IE63 protein | recombinant wild-type and mutant IE63 proteins expressed in Vero cells, phosphorylation at Ser224 of wild-type and mutants T222E and T222A by CDK1 and CDK5, but not by CDK2, CDK7, and CDK9 in vitro, mutant S224A is no substrate | Chlorocebus aethiops | ADP + phosphorylated Varicella-Zoster virus IE63 protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk1 | - |
Chlorocebus aethiops |
| CDK2 | - |
Chlorocebus aethiops |
| Cdk5 | - |
Chlorocebus aethiops |
| cdk7 | - |
Chlorocebus aethiops |
| CDK9 | - |
Chlorocebus aethiops |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Chlorocebus aethiops |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Chlorocebus aethiops |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Chlorocebus aethiops | |
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