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Literature summary for 2.7.11.22 extracted from

  • Li, B.S.; Ma, W.; Jaffe, H.; Zheng, Y.; Takahashi, S.; Zhang, L.; Kulkarni, A.B.; Pant, H.C.
    Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival (2003), J. Biol. Chem., 278, 35702-35709.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
p35 the cyclin is the regulatory subunit, dependent on Mus musculus
p35 the cyclin is the regulatory subunit, dependent on Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of Cdk5-p35 and HA-tagged Erb3, wild-type and mutants T871A and S1120A, or HA-tagged Erb2, wild-type and mutant S1176A, in COS-7 cells, in contrast to the wild-type substrates, the mutant substrates are not phosphorylated by Cdk5 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information null mutant mice show lower phosphatidylinositol 3-kinase activity and phosphorylation of Akt in brain compared to wild-type mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
roscovitine
-
 Mus musculus
roscovitine
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + neuregulin receptor ErbB2 Mus musculus phosphorylation at Ser1176 by Cdk5 ADP + phosphorylated neuregulin receptor ErbB2
-
 ?
ATP + neuregulin receptor ErbB3 Rattus norvegicus phosphorylation at Thr871 and Ser1120 by Cdk5 ADP + phosphorylated neuregulin receptor ErbB3
-
 ?
ATP + neuregulin receptor ErbB3 Mus musculus phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo ADP + phosphorylated neuregulin receptor ErbB3
-
 ?
additional information Mus musculus Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection ?
-
 ?
additional information Rattus norvegicus Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
neuron cortical Rattus norvegicus
-
neuron cortical, co-localization of Cdk5 and Erb3 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1 commercial substrate, Cdk5 Mus musculus ADP + phosphorylated histone H1
-
 ?
ATP + neuregulin receptor ErbB2 phosphorylation at Ser1176 by Cdk5 Mus musculus ADP + phosphorylated neuregulin receptor ErbB2
-
 ?
ATP + neuregulin receptor ErbB2 phosphorylation at Ser1176 in the sequence RPKTLSPGKN by Cdk5 Mus musculus ADP + phosphorylated neuregulin receptor ErbB2
-
 ?
ATP + neuregulin receptor ErbB3 phosphorylation at Thr871 and Ser1120 by Cdk5 Rattus norvegicus ADP + phosphorylated neuregulin receptor ErbB3
-
 ?
ATP + neuregulin receptor ErbB3 phosphorylation at Thr871 and Ser1120 in the consensus sequence RSRSPR by Cdk5, Cdk5 associates with Erb3 in vivo Mus musculus ADP + phosphorylated neuregulin receptor ErbB3
-
 ?
ATP + neuregulin receptor ErbB3 phosphorylation at Thr871 in the sequence AKTPIKWAL and Ser1120 in the consensus sequence RSRSPR by Cdk5, weak phosphorylation of Ser1204 in the proline-rich sequence RRGSPPRPPR Mus musculus ADP + phosphorylated neuregulin receptor ErbB3
-
 ?
additional information Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection Mus musculus ?
-
 ?
additional information Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Mus musculus
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase-5
-
 Mus musculus
cyclin-dependent kinase-5
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus