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Literature summary for 2.7.11.22 extracted from

  • Dou, X.; Wu, D.; An, W.; Davies, J.; Hashmi, S.B.; Ukil, L.; Osmani, S.A.
    The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans (2003), Genetics, 165, 1105-1115.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genes phoA and phoB, DNA and amino acid sequence determination and analysis Aspergillus nidulans

Protein Variants

Protein Variants Comment Organism
K39R site-directed mutagenesis, negative dominant kinase inactive mutant of PHOA, mutant strain shows defects in cell cycle and nuclear division Aspergillus nidulans
additional information construction of PHOA and PHOB null mutant strains, deletion of PHOB causes no phenotype, while deletion of PHOA inhibits growth, a double null mutant shows defects in cell cycle and nuclear division and is lethal, overview, complementation of the double null mutant with expression of human CDK5 Aspergillus nidulans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 x * 34000, PHOB, SDS-PAGE Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aspergillus nidulans the CDKs PHOA is involved in modulation of differentiation in response to environmental conditions, including limited phosphorous, but does not play an essential role in regulation of phosphorous aquisition ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
 several strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the CDKs PHOA is involved in modulation of differentiation in response to environmental conditions, including limited phosphorous, but does not play an essential role in regulation of phosphorous aquisition Aspergillus nidulans ?
-
 ?

Subunits

Subunits Comment Organism
? x * 34000, PHOB, SDS-PAGE Aspergillus nidulans

Synonyms

Synonyms Comment Organism
CDK
-
 Aspergillus nidulans
PHOA
-
 Aspergillus nidulans
PHOB
-
 Aspergillus nidulans

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Aspergillus nidulans