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Literature summary for 2.7.11.22 extracted from

  • Pu, R.T.; Osmani, S.A.
    Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit (1995), EMBO J., 14, 995-1003.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information partial C-terminal deletion of NIMA generates a highly toxic kinase although the kinase domain alone is not toxic Aspergillus nidulans

General Stability

General Stability Organism
partially truncated NIMA is far more stable than the full length NIMA protein which likely accounts for its toxicity Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Aspergillus nidulans NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans ADP + phosphoprotein
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Organism

Organism UniProt Comment Textmining
Aspergillus nidulans P11837
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Source Tissue

Source Tissue Comment Organism Textmining
mitotic cell NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis Aspergillus nidulans
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additional information NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis Aspergillus nidulans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans Aspergillus nidulans ADP + phosphoprotein
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 ?

Synonyms

Synonyms Comment Organism
G2-specific protein kinase NIMA
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 Aspergillus nidulans
NIMA protein kinase
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 Aspergillus nidulans