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Literature summary for 2.7.11.22 extracted from
- Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling (1995), Cell, 80, 225-236.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cyclin | e.g. cyclin A and cyclin B, dependent on, forms a subunit of the enzyme after binding | eukaryota | |
| additional information | regulation by reversible phosphorylation, activation by e.g. CAK, i.e. cyclin-dependent kinase activating kinase, overview | eukaryota |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | regulation by reversible phosphorylation, overview | eukaryota |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | CAK | eukaryota | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
eukaryota |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
| additional information | eukaryota | regulation mechanisms, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | regulation by de-/phosphorylation at Thr residues, overview, phosphorylation has both negative and positive regulating function, overview, CAK phoshorylates and activates cdc2 PK, cdk7 phosphorylates and activates CAK | eukaryota |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| ATP + CAK | substrate of cyclin-dependent kinase cdk7 | eukaryota | ADP + phosphorylated CAK | - |
? | |
| ATP + cdc2 PK | substrate of cyclin-dependent kinase activating kinase CAK | eukaryota | ADP + phosphorylated cdc2 PK | - |
? | |
| additional information | regulation mechanisms, overview | eukaryota | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | active for, with cyclin bound as second subunit | eukaryota |
| monomer | inactive form | eukaryota |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAK | - |
eukaryota |
| cdc2 PK | - |
eukaryota |
| cdk7 | - |
eukaryota |
| cyclin-dependent kinase activating kinase | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
eukaryota | |
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