Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin | e.g. cyclin A and cyclin B, dependent on, forms a subunit of the enzyme after binding | eukaryota | |
additional information | regulation by reversible phosphorylation, activation by e.g. CAK, i.e. cyclin-dependent kinase activating kinase, overview | eukaryota |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | regulation by reversible phosphorylation, overview | eukaryota |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | CAK | eukaryota | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
eukaryota |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
additional information | eukaryota | regulation mechanisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
eukaryota | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | regulation by de-/phosphorylation at Thr residues, overview, phosphorylation has both negative and positive regulating function, overview, CAK phoshorylates and activates cdc2 PK, cdk7 phosphorylates and activates CAK | eukaryota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
ATP + CAK | substrate of cyclin-dependent kinase cdk7 | eukaryota | ADP + phosphorylated CAK | - |
? | |
ATP + cdc2 PK | substrate of cyclin-dependent kinase activating kinase CAK | eukaryota | ADP + phosphorylated cdc2 PK | - |
? | |
additional information | regulation mechanisms, overview | eukaryota | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | active for, with cyclin bound as second subunit | eukaryota |
monomer | inactive form | eukaryota |
Synonyms | Comment | Organism |
---|---|---|
CAK | - |
eukaryota |
cdc2 PK | - |
eukaryota |
cdk7 | - |
eukaryota |
cyclin-dependent kinase activating kinase | - |
eukaryota |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
eukaryota |