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Literature summary for 2.7.11.21 extracted from

  • Murugan, R.N.; Park, J.E.; Lim, D.; Ahn, M.; Cheong, C.; Kwon, T.; Nam, K.Y.; Choi, S.H.; Kim, B.Y.; Yoon, D.Y.; Yaffe, M.B.; Yu, D.Y.; Lee, K.S.; Bang, J.K.
    Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1 (2013), Bioorg. Med. Chem., 21, 2623-2634.
    View publication on PubMed
Search for more literature for 2.7.11.21

Inhibitors

Inhibitors Comment Organism Structure
cyclic (-CH2-CO-Pro-Leu-His-Ser-pThr-Cys-S-)
-
 Homo sapiens
cyclic [-CH2-CO-N[2-(1H-indol-3-yl)ethyl]-CH2-CO-Leu-His-Ser-pThr-NH-CH[CONH2]-CH2-S-]
-
 Homo sapiens
cyclic [-CH2-CO-N[3-[[2-(1H-indol-3-yl)ethyl]amino]-3-oxopropyl]-CH2-CO-Leu-His-Ser-p-Thr-NH-CH[CONH2]-CH2-S-]
-
 Homo sapiens
cyclic [-CH2-CO-N[6-[[2-(1-acetyl-1H-indol-3-yl)ethyl]amino]-6-oxohexyl]-CH2-CO-Leu-His-Ser-pThr-NH-CH[CONH2]-CH2-S-]
-
 Homo sapiens
cyclic [-CH2-CO-N[6-[[2-(1-acetyl-1H-indol-3-yl)ethyl]amino]-6-oxohexyl]-CH2-CO-Leu-His[N3-(8-phenyloctyl)]-Ser-pThr-NH-CH[CONH2]-CH2-S-]
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
 25°C, pH not specified in the publication Homo sapiens cyclic [-CH2-CO-N[6-[[2-(1-acetyl-1H-indol-3-yl)ethyl]amino]-6-oxohexyl]-CH2-CO-Leu-His[N3-(8-phenyloctyl)]-Ser-pThr-NH-CH[CONH2]-CH2-S-]
0.0026
-
 25°C, pH not specified in the publication Homo sapiens cyclic [-CH2-CO-N[6-[[2-(1-acetyl-1H-indol-3-yl)ethyl]amino]-6-oxohexyl]-CH2-CO-Leu-His-Ser-pThr-NH-CH[CONH2]-CH2-S-]
0.0048
-
 25°C, pH not specified in the publication Homo sapiens cyclic [-CH2-CO-N[3-[[2-(1H-indol-3-yl)ethyl]amino]-3-oxopropyl]-CH2-CO-Leu-His-Ser-p-Thr-NH-CH[CONH2]-CH2-S-]
0.0085
-
 25°C, pH not specified in the publication Homo sapiens cyclic [-CH2-CO-N[2-(1H-indol-3-yl)ethyl]-CH2-CO-Leu-His-Ser-pThr-NH-CH[CONH2]-CH2-S-]
0.0098
-
 25°C, pH not specified in the publication Homo sapiens cyclic (-CH2-CO-Pro-Leu-His-Ser-pThr-Cys-S-)