Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.21 extracted from

  • Sun, D.; Luthra, P.; Li, Z.; He, B.
    PLK1 down-regulates parainfluenza virus 5 gene expression (2009), PLoS Pathog., 5, e1000525.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Application

Application Comment Organism
medicine it is possible that targeting PLK1 will enhance host innate immune responsees, leading to a novel strategy of clearing paramyxovirus infections quickly Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into the pCAGGS vector Homo sapiens

Protein Variants

Protein Variants Comment Organism
K82M kinase-deficient PLK1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BI 2536
-
 Homo sapiens
GW843682
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?
ATP + viral phosphoprotein P PLK1 directly phosphorylates viral phosphoprotein P of paramyxovirus in vitro Homo sapiens ADP + phosphorylated viral phosphoprotein P
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 kinase assay at room temperature Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PLK1 plays a critical role in regulating the cell cycle, PLK inhibition increases gene expression of paramyxovirus Homo sapiens