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Literature summary for 2.7.11.21 extracted from

  • Sillibourne, J.E.; Tack, F.; Vloemans, N.; Boeckx, A.; Thambirajah, S.; Bonnet, P.; Ramaekers, F.C.; Bornens, M.; Grand-Perret, T.
    Autophosphorylation of polo-like kinase 4 and its role in centriole duplication (2010), Mol. Biol. Cell, 21, 547-561.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Activating Compound

Activating Compound Comment Organism Structure
additional information autophosphorylation of serine 305 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the vector pSUMO is used, an EGFP-PLK4 construct is used Homo sapiens

Protein Variants

Protein Variants Comment Organism
PLK4_1-285 fragment, kinase domain only Homo sapiens
PLK4_1-367_K41M N-terminal fragment that possesses a mutation within the catalytic domain Homo sapiens
S285A mutant Homo sapiens
S305A mutation of the autophosphorylation site Homo sapiens
S305E mutation of the autophosphorylation site Homo sapiens
T289A mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centriole
-
 Homo sapiens 5814
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q00444
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
KE-37 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
PLK4
-
 Homo sapiens
polo-like kinase 4
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 kinase assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PLK4 is a key regulator of centrosome duplication Homo sapiens