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Literature summary for 2.7.11.21 extracted from
- Targeting Polo-like kinase in cancer therapy (2010), Clin. Cancer Res., 16, 384-389.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Plk1 represents a target for anticancer therapy | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BI2536 | - |
Homo sapiens |  |
| GSK461364A | - |
Homo sapiens | |
| HMN-214 | - |
Homo sapiens | |
| ON-01910 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLK | - |
Homo sapiens |
| Plk1 | - |
Homo sapiens |
| polo-like kinase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | overexpressed in many tumor types | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Plk1 functions in multiple steps of mitosis | Homo sapiens |
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Release 2023.1 (January 2023)
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