Application | Comment | Organism |
---|---|---|
medicine | GSK461364A is broadly antiproliferative for tumor cell lines in vitro and efficacious in multiple in vivo tumor models | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GSK461364A | ATP-competitive inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | NSCLC line A549 | Homo sapiens | - |
Colo-205 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
MV-522 cell | - |
Homo sapiens | - |
MX-1 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
ZR-75-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
Plk scintillation proximity assay at room temperature | Homo sapiens |
23 | - |
kinase assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
Plk scintillation proximity assay | Homo sapiens |
7.5 | - |
kinase assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000005 | - |
GSK461364A | Ki, apparent dissociation constant, less than 0.0000005 | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Plk1 overexpression is strongly associated with cancer | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Plk1 plays an essential role in regulating the many processes involved in mitotic entry and progression | Homo sapiens |