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Literature summary for 2.7.11.21 extracted from

  • Brennan, I.M.; Peters, U.; Kapoor, T.M.; Straight, A.F.
    Polo-like kinase controls vertebrate spindle elongation and cytokinesis (2007), PLoS ONE, 2, e409.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Application

Application Comment Organism
additional information Plk1 controls both spindle elongation and cytokinesis, coordinates chromosome segregation with cytokinesis through its dual control of anaphase B and contractile ring assembly Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BI-2536 blocks contractile ring assembly by preventing the localization of Rho and Rho-GEF without affecting the assembly of the central spindle Homo sapiens
BTO-1 blocks contractile ring assembly by preventing the localization of Rho and Rho-GEF without affecting the assembly of the central spindle Homo sapiens
cyclapolin 1
-
 Homo sapiens
DAP81
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
chromosome
-
 Homo sapiens 5694
-
kinetochore
-
 Homo sapiens 776
-
spindle
-
 Homo sapiens 5819
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens
-
 ADP + phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein
-
 Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
-
 Homo sapiens BI-2536
0.008
-
-
 Homo sapiens BTO-1