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Literature summary for 2.7.11.21 extracted from
- PLK1 inhibitors: setting the mitotic death trap (2007), Curr. Biol., 17, R280-R283.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | BI 2536 is well tolerated | Mus musculus |
| drug development | roles of Plk1 in cell cycle progression and in mitosis, role for Plk1 in the activation of the CDK1-Cyclin B complex. Plk1 is required not only to obtain, but also to maintain, chromosome bi-orientation on the mitotic spindle, use of BI 2536, a small-molecule inhibitor of Plk1, as an analytical tool and potential cancer therapeutic | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BI 2536 | remarkable potency and selectivity towards Plk1, HeLa cells treated with BI 2536 are first delayed in prophase, after reluctantly entering mitosis, cells become blocked in prometaphase with aberrant monopolar spindles that fail to attach stably to chromosomes | Homo sapiens |  |
| BI 2536 | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P53350 | - |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Plk1 | - |
Mus musculus |
| Plk1 | - |
Homo sapiens |
| Polo-like kinase 1 | - |
Mus musculus |
| Polo-like kinase 1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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