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Literature summary for 2.7.11.21 extracted from

  • Lee, B.H.; Amon, A.
    Role of polo-like kinase CDC5 in programming meiosis I chromosome segregation (2003), Science, 300, 482-486.
    View publication on PubMed
Search for more literature for 2.7.11.21

Protein Variants

Protein Variants Comment Organism
additional information in mutant cells in which the Cdc5 promoter is exchanged for the Clb2 promoter, the enzyme is degradated during G1 phase and is absent in meiosis, Cdc5-depleted cells progress through premeiotic S phase and enter metaphase I but arrest in metaphase I, mechanism Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore
-
 Saccharomyces cerevisiae 776
-
nucleus
-
 Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae Cdc5 plays a role in chromosomes segregation during meiosis I, it is required for phosphorylation and removal of cohesin from chromosomes, it is required for sister-kinetochore orientation with associated Mam1 protein, mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cdc5 plays a role in chromosomes segregation during meiosis I, it is required for phosphorylation and removal of cohesin from chromosomes, it is required for sister-kinetochore orientation with associated Mam1 protein, mechanism, overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Cdc5
-
 Saccharomyces cerevisiae
polo-like kinase
-
 Saccharomyces cerevisiae