Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged Plk1 in COS-7 cells, co-expression of Plk1 and p53 in p53-deficient lung carcinoma H1299 cells greatly decreases the p53-mediated recombinant transcription, this effect does not appear with co-expression of kinase-defective K82M Plk1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K82M | site-directed mutagenesis, kinase-defective mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ataxia-telangiectasia mutant | i.e. ATM, inhibits p53 phosphorylation by Plk1 in vivo | Homo sapiens | |
additional information | Plk1 expression is decreased during ciplatin-induced apoptosis while p53 is stabilized | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | the nuclear localization sequence is 48RSRRRYVRGR57 | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + p53 | Homo sapiens | Plk1 binds tumor suppressor p53, dependent on DNA-binding to the specific DNA binding domain within residues 102-292 of p53, and inhibits its transactivation activity | ADP + phosphorylated p53 | - |
? | |
additional information | Homo sapiens | Plk1 is involved in the regulation of M-phase of the cell cycle and might also be involved in tumorigenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | neuroblastoma cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + p53 | Plk1 binds tumor suppressor p53, dependent on DNA-binding to the specific DNA binding domain within residues 102-292 of p53, and inhibits its transactivation activity | Homo sapiens | ADP + phosphorylated p53 | - |
? | |
ATP + p53 | phosphorylation at Ser20 | Homo sapiens | ADP + phosphorylated p53 | - |
? | |
additional information | Plk1 is involved in the regulation of M-phase of the cell cycle and might also be involved in tumorigenesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |