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Literature summary for 2.7.11.21 extracted from

  • Holtrich, U.; Wolf, G.; Brauninger, A.; Karn, T.; Bohme, B.; Rubsamen-Waigmann, H.; Strebhardt, K.
    Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors (1994), Proc. Natl. Acad. Sci. USA, 91, 1736-1740.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens expression of PLK mRNA appeared to be strongly correlated with the mitotic activity of cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
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-

Source Tissue

Source Tissue Comment Organism Textmining
colon
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 Homo sapiens
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additional information no PLK transcripts are found in normal adult lung, brain, heart, liver, kidney, skeletal muscle, and pancreas, resting peripheral lymphocytes do not express the gene at all. Primary cultures of human peripheral macrophages, which are not dividing under the culture conditions applied, showed very little or no PLK mRN Homo sapiens
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placenta
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 Homo sapiens
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T-cell primary, when activated by phytohemagglutinin, a high level of PLK transcripts results within 2-3 days. In some cases, addition of interleukin 2 to these cells increases the expression of PLK mRNA further Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expression of PLK mRNA appeared to be strongly correlated with the mitotic activity of cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase PLK
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 Homo sapiens