Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.2 extracted from

  • Chokkalingam, K.; Jewell, K.; Norton, L.; Littlewood, J.; van Loon, L.J.; Mansell, P.; Macdonald, I.A.; Tsintzas, K.
    High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: An important role for skeletal muscle pyruvate dehydrogenase kinase 4 (2007), J. Clin. Endocrinol. Metab., 92, 284-292.
    View publication on PubMed
Search for more literature for 2.7.11.2

Activating Compound

Activating Compound Comment Organism Structure
additional information PDK4 expression is 2fold induced in high-fat/low carbohydrate diet and is blunted under basal and clamp conditions after high-fat diet, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information insulin downregulates expression of PDK4, but not of PDK2, after high-fat and control diets, but does not regulate the PDK4 protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PDK4 is involved in metabolic changes after induction by high-fat/low carbohydrate diet, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDK4 is involved in metabolic changes after induction by high-fat/low carbohydrate diet, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PDK
-
 Homo sapiens
pyruvate dehydrogenase kinase
-
 Homo sapiens