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Literature summary for 2.7.11.2 extracted from

  • Kim, J.W.; Tchernyshyov, I.; Semenza, G.L.; Dang, C.V.
    HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia (2006), Cell Metab., 3, 177-185.
    View publication on PubMed
Search for more literature for 2.7.11.2

Activating Compound

Activating Compound Comment Organism Structure
additional information hypoxia-inducible factor HIF-1 induces PDK1 expression, PDK1 is a direct target gene of HIF-1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of PDK1 increases the ATP levels and prevents hypoxia-induced reactive oxygen species generation and apoptosis, hypoxia-inducible factor HIF-1 knockout embryonic fibroblasts fail to activate PDK1 and undergo apoptosis with a high rise in reactive oxygen species, hypoxic P493-6 cells with reduced PDK1 levels show impaired growth Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens hypoxia-inducible factor HIF-1, inducible e.g. by CoCl2, mediates the expression of PDK1, which inhibits the pyruvate dehydrogenase in the tricarboxylic cycle by phosphorylation, high PDK1 activity increases the ATP levels and prevents hypoxia-induced reactive oxygen species generation and apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast cell line Homo sapiens
-
P493-6 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hypoxia-inducible factor HIF-1, inducible e.g. by CoCl2, mediates the expression of PDK1, which inhibits the pyruvate dehydrogenase in the tricarboxylic cycle by phosphorylation, high PDK1 activity increases the ATP levels and prevents hypoxia-induced reactive oxygen species generation and apoptosis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PDK
-
 Homo sapiens
pyruvate dehydrogenase kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens