Activating Compound | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex | Bos taurus | |
acetyl-CoA | high stimulation through acetylation of the transacetylase-catalyzing inner core portion of the dihydrolipoyl acetyltransferase | Bos taurus | |
dihydrolipoyl transacetylase | involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex | Bos taurus | |
dihydrolipoyl transacetylase | binding and activation mechanism | Bos taurus | |
NADH | involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex | Bos taurus | |
pyruvate | at low concentration, with the thiamine diphosphate containing pyruvate dehydrogenase complex, stimulation mechanism | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Bos taurus |