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Literature summary for 2.7.11.19 extracted from

  • Nadeau, O.W.; Anderson, D.W.; Yang, Q.; Artigues, A.; Paschall, J.E.; Wyckoff, G.J.; McClintock, J.L.; Carlson, G.M.
    Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides (2007), J. Mol. Biol., 365, 1429-1445.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
additional information location of an allosteric activation switch in the multisubunit phosphorylase kinase complex, overview Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
two-hybrid plasmid construction of fusions containing the PhK beta subunit and its deletion mutants and expression in a yeast two-hybrid system Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
additional information construction of PhKbeta subunit deletion mutants Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Oryctolagus cuniculus
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycogen phosphorylase b Oryctolagus cuniculus
-
 ADP + phosphorylated glycogen phosphorylase b
-
 ?
additional information Oryctolagus cuniculus the enzyme complex regulates glycogenolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein subunit PhKalpha is autophosphorylated Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment) Organism
native enzyme from psoas muscle Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
psoas
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen phosphorylase b
-
 Oryctolagus cuniculus ADP + phosphorylated glycogen phosphorylase b
-
 ?
ATP + glycogen S peptide synthetic peptide corresponding to residues 5-18 of its convertible region Oryctolagus cuniculus ADP + phosphorylated glycogen S peptide
-
 ?
additional information the enzyme complex regulates glycogenolysis Oryctolagus cuniculus ?
-
 ?
additional information subunit PhKalpha is autophosphorylated Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
tetramer the enzyme forms a (alphabetagammadelta)4 complex, location of an allosteric activation switch in the multisubunit phosphorylase kinase complex, overview Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
PhK
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at, substrate glycogen phosphorylase b Oryctolagus cuniculus
8.3
-
 assay at, substrate glycogen S peptide Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus