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Literature summary for 2.7.11.19 extracted from

  • Vandenheede, J.R.; De Wulf, H.; Merlevede, W.
    Liver phosphorylase b kinase. Cyclic-AMP-mediated activation and properties of the partially purified rat-liver enzyme (1979), Eur. J. Biochem., 101, 51-58.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
adenosine 3',5'-monophosphate cAMP mediated activation Rattus norvegicus
adenosine 3',5'-monophosphate cAMP mediated activation Oryctolagus cuniculus

General Stability

General Stability Organism
unstable in dilute solutions Rattus norvegicus
unstable in dilute solutions Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
Oryctolagus cuniculus
EGTA
-
Rattus norvegicus
Mg2+ in excess of ATP; nonactivated and activated enzyme Oryctolagus cuniculus
Mg2+ in excess of ATP; nonactivated and activated enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
additional information
-
additional information
-
Oryctolagus cuniculus
0.07
-
MgATP2- activated rabbit skeletal muscle enzyme, pH 8.2 Rattus norvegicus
0.07
-
MgATP2- activated rabbit skeletal muscle enzyme, pH 8.2 Oryctolagus cuniculus
0.08
-
MgATP2- activated rabbit skeletal muscle enzyme, pH 6 Rattus norvegicus
0.08
-
MgATP2- activated rabbit skeletal muscle enzyme, pH 6 Oryctolagus cuniculus
0.1
-
MgATP2- nonactivated rabbit skeletal muscle enzyme, pH 6 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-
soluble
-
Rattus norvegicus
-
-
soluble
-
Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for efficient substrate binding of active and nonactivated enzyme and for maximal catalysis of active enzyme Rattus norvegicus
Ca2+ required for efficient substrate binding of active and nonactivated enzyme and for maximal catalysis of active enzyme Oryctolagus cuniculus
Mg2+ requirement Rattus norvegicus
Mg2+ requirement Oryctolagus cuniculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Rattus norvegicus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
phosphate requirement, phosphate containing enzyme Rattus norvegicus
phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1300000
-
rat, gel filtration Rattus norvegicus
1300000
-
rat, gel filtration Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
male Wistar
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
skeletal muscle
-
Rattus norvegicus
-
skeletal muscle
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus
additional information
-
-
Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
-20°C, in 0.25 M sucrose, 0.1 M Tris-HCl, 0.5 mM DTT, pH 7.4, 50% glycerol, several weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen synthase inactivation of skeletal muscle glycogen synthase in the presence or absence of EGTA Rattus norvegicus ADP + phosphoglycogen synthase
-
?
ATP + glycogen synthase inactivation of skeletal muscle glycogen synthase in the presence or absence of EGTA Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
?
ATP + glycogen synthase at high concentration, from rabbit skeletal muscle Rattus norvegicus ADP + phosphoglycogen synthase
-
?
ATP + glycogen synthase at high concentration, from rabbit skeletal muscle Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Rattus norvegicus ADP + phosphorylase a
-
?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
?
ATP + phosphorylase b rabbit skeletal muscle Rattus norvegicus ADP + phosphorylase a
-
?
ATP + phosphorylase b rabbit skeletal muscle Oryctolagus cuniculus ADP + phosphorylase a
-
?
additional information histone H2B is no substrate Rattus norvegicus ?
-
?
additional information histone H2B is no substrate Oryctolagus cuniculus ?
-
?
additional information no spontaneous or MnSO4-induced dephosphorylation of activated enzyme Rattus norvegicus ?
-
?
additional information no spontaneous or MnSO4-induced dephosphorylation of activated enzyme Oryctolagus cuniculus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus
30
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
nonactivated enzyme Rattus norvegicus
7
-
-
Oryctolagus cuniculus
7
-
above, activated enzyme Rattus norvegicus