Literature summary for 2.7.11.18 extracted from

Zhang, W.C.; Peng, Y.J.; Zhang, G.S.; He, W.Q.; Qiao, Y.N.; Dong, Y.Y.; Gao, Y.Q.; Chen, C.; Zhang, C.H.; Li, W.; Shen, H.H.; Ning, W.; Kamm, K.E.; Stull, J.T.; Gao, X.; Zhu, M.S.
Myosin light chain kinase is necessary for tonic airway smooth muscle contraction (2010), J. Biol. Chem., 285, 5522-5531.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required for activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bronchial smooth muscle cell	-	Mus musculus	-
tracheal smooth muscle cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + myosin regulatory light chain	-	Mus musculus	ADP + myosin regulatory light chain phosphate	-	?

Synonyms

Synonyms	Comment	Organism
MLCK	-	Mus musculus
myosin light chain kinase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus
Calmodulin	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	MLCK-deficient mice lack bronchial constrictions in normal and asthmatic airways, while the asthmatic inflammation response is not affected	Mus musculus
physiological function	myosin light chain kinase acts as a central participant in the contractile signaling module of tonic smooth muscle	Mus musculus

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Release 2023.1 (January 2023)