Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Mus musculus | |
additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Homo sapiens | |
additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
obscurin-associated kinase, DNA and amino acid sequence determination, sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview. Expression in Escherichia coli strain BL21(DE3) | Homo sapiens |
sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview | Mus musculus |
sequence and expression analysis and comparison, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Homo sapiens | |
additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Mus musculus | |
additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | exclusively | Mus musculus | 5737 | - |
cytoplasm | exclusively | Homo sapiens | 5737 | - |
cytoplasm | exclusively | Rattus norvegicus | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | Mus musculus | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Homo sapiens | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Rattus norvegicus | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
ATP + obscurin | Mus musculus | - |
ADP + obscurin phosphate | - |
? | |
ATP + obscurin | Homo sapiens | - |
ADP + obscurin phosphate | - |
? | |
ATP + obscurin | Rattus norvegicus | - |
ADP + obscurin phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Mus musculus |
phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Homo sapiens |
phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | primary cell culture | Mus musculus | - |
cardiac myocyte | primary cell culture | Homo sapiens | - |
cardiac myocyte | primary cell culture | Rattus norvegicus | - |
heart | ventricle | Mus musculus | - |
heart | ventricle | Homo sapiens | - |
heart | ventricle | Rattus norvegicus | - |
additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Mus musculus | - |
additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Homo sapiens | - |
additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Rattus norvegicus | - |
muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Mus musculus | - |
muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Homo sapiens | - |
muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Rattus norvegicus | - |
myocardium | expression analysis, overview | Mus musculus | - |
myocardium | expression analysis, overview | Homo sapiens | - |
myocardium | expression analysis, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | - |
Mus musculus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Mus musculus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
ATP + obscurin | - |
Mus musculus | ADP + obscurin phosphate | - |
? | |
ATP + obscurin | - |
Homo sapiens | ADP + obscurin phosphate | - |
? | |
ATP + obscurin | - |
Rattus norvegicus | ADP + obscurin phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Mus musculus |
MLCK | - |
Homo sapiens |
MLCK | - |
Rattus norvegicus |
myosin light chain kinase | - |
Mus musculus |
myosin light chain kinase | - |
Homo sapiens |
myosin light chain kinase | - |
Rattus norvegicus |
obscurin-associated kinase | - |
Mus musculus |
obscurin-associated kinase | - |
Homo sapiens |
obscurin-associated kinase | - |
Rattus norvegicus |
obscurin-MLCK-like kinase | - |
Mus musculus |
obscurin-MLCK-like kinase | - |
Homo sapiens |
obscurin-MLCK-like kinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |