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Literature summary for 2.7.11.18 extracted from
- A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs (2006), Mol. Biol. Cell, 17, 4093-4104.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| blebbistatin | complete inhibition at 0.1 mM | Lytechinus pictus |  |
| cytasters | low inhibition | Lytechinus pictus | |
| H1152 | low inhibition | Lytechinus pictus | |
| ML-7 | - |
Lytechinus pictus | |
| MLCK pepitde | complete inhibition | Lytechinus pictus | |
| additional information | no inhibition by nocodazone | Lytechinus pictus | |
| Rho GDI | - |
Lytechinus pictus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microtubule | astral | Lytechinus pictus | 5874 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Lytechinus pictus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + light chain myosin II | Lytechinus pictus | roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview | ADP + phosphorylated light chain myosin II | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lytechinus pictus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | at the equator of dividing cells | Lytechinus pictus | - |
| additional information | subcellular localization | Lytechinus pictus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + light chain myosin II | roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview | Lytechinus pictus | ADP + phosphorylated light chain myosin II | - |
? | |
| ATP + light chain myosin II | phosphorylation at Ser19 | Lytechinus pictus | ADP + phosphorylated light chain myosin II | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
Lytechinus pictus |
| myosin light chain kinase | - |
Lytechinus pictus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Lytechinus pictus | |
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Release 2023.1 (January 2023)
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