Cloned (Comment) | Organism |
---|---|
expression of wild-type and dominant-negative MLCK in untransformed and Ras-transformed MCF-10A cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a dominant-negative MLCK mutant | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML-7 | inhibition of MLCK induces apoptosis in adherent cells and disrupts cell-cell adhesion | Mus musculus | |
ML-9 | inhibition of MLCK induces apoptosis in adherent cells and disrupts cell-cell adhesion | Mus musculus | |
additional information | no inhibition in vivo by Y-27632 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | Mus musculus | myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | Mus musculus | the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | - |
Mus musculus | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events | Mus musculus | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Mus musculus |
myosin light chain kinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |