Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.18 extracted from

  • Ryder, J.W.; Lau, K.S.; Kamm, K.E.; Stull, J.T.
    Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase (2007), J. Biol. Chem., 282, 20447-20454.
    View publication on PubMed
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin a calmodulin-sensitive MLCK isozyme Oryctolagus cuniculus
additional information electric stimulation of intact skeletal muscles activate the enzyme activity, overview Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in transgenic mice, expression in COS cells Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice that express an skeletal muscle-MLCK, i.e. skMLCK, CaM biosensor in skeletal muscle to determine whether skMLCK or calmodulin is limiting to twitch force potentiation. Three transgenic mouse lines exhibited up to 22-fold increases in skMLCK protein expression in fast-twitch extensor digitorum longus muscle containing type IIa and IIb fibers, with comparable expressions in slow-twitch soleus muscle containing type I and IIa fibers, overview Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Oryctolagus cuniculus
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + light chain myosin II Oryctolagus cuniculus MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview ADP + phosphorylated light chain myosin II
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + light chain myosin II MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview Oryctolagus cuniculus ADP + phosphorylated light chain myosin II
-
 ?
ATP + light chain myosin II regulatory myosin chain Oryctolagus cuniculus ADP + phosphorylated light chain myosin II
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Oryctolagus cuniculus
More cf. EC 2.7.11.17 Oryctolagus cuniculus
myosin light chain kinase
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus