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Literature summary for 2.7.11.18 extracted from

  • Behling-Kelly, E.; McClenahan, D.; Kim, K.S.; Czuprynski, C.J.
    Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance (2007), Infect. Immun., 75, 4572-4581.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
additional information tumor necrosis factor-alpha induces enzyme activity in vivo Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
ML-7
-
 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + light chain myosin II Bos taurus causes endothelial contraction ADP + phosphorylated light chain myosin II
-
 ?
additional information Bos taurus infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-
brain endothelium cell line a SV40-infected endothelial cell line Bos taurus
-
central nervous system
-
 Bos taurus
-
endothelial cell brain Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + light chain myosin II
-
 Bos taurus ADP + phosphorylated light chain myosin II
-
 ?
ATP + light chain myosin II causes endothelial contraction Bos taurus ADP + phosphorylated light chain myosin II
-
 ?
additional information infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Bos taurus
myosin light-chain kinase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus