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Literature summary for 2.7.11.18 extracted from

  • Gu, L.Z.; Hu, W.Y.; Antic, N.; Mehta, R.; Turner, J.R.; de Lanerolle, P.
    Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells (2006), Eur. J. Cancer, 42, 948-957.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ML-7 specific inhibitor of MLCK, has a chemopreventive effect in an in vitro mouse mammary organ culture model, in vivo the inhibitor retards the growth of mammary tumours, acts as an adjuvant to etoposide stimulating its ability to prevent growth of established tomours, overview Mus musculus
ML-7 specific inhibitor of MLCK, in vivo the inhibitor retards the growth of prostate tumours, acts as an adjuvant to etoposide stimulating its ability to prevent growth of established tomours, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus inhibition of the enzyme retards the growth of mammary cancer cells ?
-
?
additional information Rattus norvegicus inhibition of the enzyme retards the growth of prostate cancer cells ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Mat-Ly-Lu cell a prostate cancer cell line Rattus norvegicus
-
Mm5MT cell a mammary adenocarcinoma cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inhibition of the enzyme retards the growth of mammary cancer cells Mus musculus ?
-
?
additional information inhibition of the enzyme retards the growth of prostate cancer cells Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
MLCK
-
Mus musculus
MLCK
-
Rattus norvegicus
myosin light chain kinase
-
Mus musculus
myosin light chain kinase
-
Rattus norvegicus