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Literature summary for 2.7.11.18 extracted from

  • Tokumitsu, H.; Hatano, N.; Inuzuka, H.; Ishikawa, Y.; Uyeda, T.Q.; Smith, J.L.; Kobayashi, R.
    Regulatory mechanism of Dictyostelium myosin light chain kinase A (2004), J. Biol. Chem., 279, 42-50.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information 140fold activation through phosphorylation at Thr166 Dictyostelium discoideum

Inhibitors

Inhibitors Comment Organism Structure
additional information residues 283-288 function as an autoinhibitory domain, autoinhibition is fully relieved by Thr166 phosphorylation Dictyostelium discoideum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum P25323
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is 140fold activated through phosphorylation at Thr166 by a recombinant constitutively active Ca2+/calmodulin-dependent protein kinase kinase, the enzyme performs autophosphorylation at Thr289, subsequent to Thr166 phosphorylation by the protein kinase kinase, and at several serine residues, leading to release of the autoinhibitory domain from the catalytic core, identification of phosphorylation sites Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + kemptamide i.e. peptide KKRPQRATSNVFS-NH2, activated enzyme Dictyostelium discoideum ADP + kemptamide phosphate
-
?
ATP + myosin II from Dictyostelium discoideum, activated enzyme Dictyostelium discoideum ADP + myosin II phosphate
-
?
ATP + [myosin II light chain] from Dictyostelium discoideum, activated enzyme Dictyostelium discoideum ADP + [myosin II lihght chain] phosphate
-
?

Synonyms

Synonyms Comment Organism
MLCK-A
-
Dictyostelium discoideum
myosin light chain kinase A
-
Dictyostelium discoideum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Dictyostelium discoideum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Dictyostelium discoideum