Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoprenaline | 80% activation at up to 0.01 mM | Homo sapiens | |
phenylephrine | 80% activation at up to 0.1 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML-7 | strong specific inhibition | Homo sapiens | |
Wortmannin | complete inhibition at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [myosin light chain 2a] | Homo sapiens | MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae | ADP + [myosin light chain 2a] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atrium | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [myosin light chain 2a] | - |
Homo sapiens | ADP + [myosin light chain 2a] phosphate | - |
? | |
ATP + [myosin light chain 2a] | MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae | Homo sapiens | ADP + [myosin light chain 2a] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLC kinase | - |
Homo sapiens |
MLCK | - |
Homo sapiens |
myosin light chain kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |