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Literature summary for 2.7.11.18 extracted from

  • Padre, R.C.; Stull, J.T.
    Conformational requirements for Ca2+/calmodulin binding and activation of myosin light chain kinase (2000), FEBS Lett., 472, 148-152.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 african green monkey kidney cells Oryctolagus cuniculus

Protein Variants

Protein Variants Comment Organism
A983P dramatic increase in Ca2+ required for half-maximal activity Oryctolagus cuniculus
A986P significantly increase in Ca2+ required for half-maximal activity, slightly decreased KM for regulatory light chain Oryctolagus cuniculus
M968P 10% Ca2+/calmodulin independent activity of total activity, decreased KM for regulatory light chain Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0067
-
myosin regulatory light chain pH 7, M968P Oryctolagus cuniculus
0.011
-
myosin regulatory light chain pH 7, A986P Oryctolagus cuniculus
0.014
-
myosin regulatory light chain pH 7, wild type Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin regulatory light chain
-
Oryctolagus cuniculus ?
-
?