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Literature summary for 2.7.11.18 extracted from
- Structure and function of a calmodulin-dependent smooth muscle myosin light chain kinase (1984), Experientia, 40, 1185-1188.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| naphthalene sulfonamide derivatives | - |
Bos taurus | |
| naphthalene sulfonamide derivatives | - |
Gallus gallus | |
| naphthalene sulfonamide derivatives | - |
Meleagris gallopavo | |
| naphthalene sulfonamide derivatives | - |
Oryctolagus cuniculus | |
| phosphorylation | at 2 sites | Bos taurus | |
| phosphorylation | at 2 sites | Gallus gallus | |
| phosphorylation | at 2 sites | Meleagris gallopavo | |
| phosphorylation | at 2 sites | Oryctolagus cuniculus | |
| Trifluoperazine | - |
Bos taurus |  |
| Trifluoperazine | - |
Gallus gallus | |
| Trifluoperazine | - |
Meleagris gallopavo | |
| Trifluoperazine | - |
Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Gallus gallus | |
| Ca2+ | - |
Meleagris gallopavo | |
| Ca2+ | - |
Bos taurus | |
| Ca2+ | - |
Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Meleagris gallopavo |
| additional information | - |
- |
Bos taurus |
| additional information | - |
- |
Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | Gallus gallus | - |
ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | Meleagris gallopavo | - |
ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | Bos taurus | - |
ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | Oryctolagus cuniculus | - |
ADP + myosin light chain phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Meleagris gallopavo | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gizzard | - |
Gallus gallus | - |
| gizzard | - |
Meleagris gallopavo | - |
| smooth muscle | - |
Gallus gallus | - |
| smooth muscle | - |
Meleagris gallopavo | - |
| smooth muscle | - |
Bos taurus | - |
| smooth muscle | - |
Oryctolagus cuniculus | - |
| stomach | - |
Gallus gallus | - |
| stomach | - |
Meleagris gallopavo | - |
| stomach | - |
Bos taurus | - |
| stomach | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | - |
Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | - |
Meleagris gallopavo | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | - |
Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | - |
Oryctolagus cuniculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle myosin | Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle myosin | Meleagris gallopavo | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle myosin | Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle myosin | Oryctolagus cuniculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is casein | Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is casein | Meleagris gallopavo | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is casein | Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is casein | Oryctolagus cuniculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle | Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle | Meleagris gallopavo | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle | Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | acceptor substrates are myosin light chains of smooth muscle | Oryctolagus cuniculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is phosphorylase b | Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is phosphorylase b | Meleagris gallopavo | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is phosphorylase b | Bos taurus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | no substrate is phosphorylase b | Oryctolagus cuniculus | ADP + myosin light chain phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | skeletal muscle enzyme structure: overall asymmetric shape, globular head and tail region | Gallus gallus |
| More | skeletal muscle enzyme structure: overall asymmetric shape, globular head and tail region | Meleagris gallopavo |
| More | skeletal muscle enzyme structure: overall asymmetric shape, globular head and tail region | Bos taurus |
| More | skeletal muscle enzyme structure: overall asymmetric shape, globular head and tail region | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | 8 | - |
Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | requirement | Gallus gallus | |
| Calmodulin | requirement | Meleagris gallopavo | |
| Calmodulin | requirement | Bos taurus | |
| Calmodulin | requirement | Oryctolagus cuniculus | |
| Calmodulin | trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin | Gallus gallus | |
| Calmodulin | trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin | Meleagris gallopavo | |
| Calmodulin | trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin | Bos taurus | |
| Calmodulin | trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin | Oryctolagus cuniculus | |
| Calmodulin | 1:1 stoichiometric complex in the presence of Ca2+ | Gallus gallus | |
| Calmodulin | 1:1 stoichiometric complex in the presence of Ca2+ | Meleagris gallopavo | |
| Calmodulin | 1:1 stoichiometric complex in the presence of Ca2+ | Bos taurus | |
| Calmodulin | 1:1 stoichiometric complex in the presence of Ca2+ | Oryctolagus cuniculus | |
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