Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.18 extracted from

  • Higashi, K.; Fukunaga, K.; Matsui, K.; Maeyama, M.; Miyamoto, E.
    Purification and characterization of myosin light-chain kinase from porcine myometrium and its phosphorylation and modulation by cyclic AMP-dependent protein kinase (1983), Biochim. Biophys. Acta, 747, 232-240.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
autophosphorylation no activation Sus scrofa
additional information no activation by phosphatidylserine Sus scrofa
additional information no activation by cAMP Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
cAMP-dependent protein kinase phosphorylates light chain myosin kinase leading to decreased affinity from calmodulin Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02 0.027 turkey gizzard myosin light chain 30°C, pH 7 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Km-value: 0.0003 Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
x * 130000, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Sus scrofa
-
ADP + myosin light chain phosphate
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
myometrium
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.9
-
-
Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, quite unstable on storage Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain no substrate is protamine Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain no substrate is casein Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain highly specific for regulatory or P-light-chain Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain highly specific for 18 kDa light chain Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain no substrate is phosphorylase kinase Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain specific for 20 kDa light chain Sus scrofa ADP + myosin light chain phosphate
-
?
ATP + myosin light chain no substrate is phosphorylase b Sus scrofa ADP + myosin light chain phosphate
-
?
additional information no intramolecular autophosphorylation in the absence of acceptor substrate Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
? x * 130000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Sus scrofa
Calmodulin lower affinity for Ca2+/caldesmon after phosphorylation by cAMP-dependent protein kinase, Ka: 0.0000006 mM Sus scrofa