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Literature summary for 2.7.11.18 extracted from

  • Garcia, J.G.N.; Lazar, V.; Gilbert-McClain, L.I.; Gallagher, P.J.; Verin, A.D.
    Myosin light chain kinase in endothelium: molecular cloning and regulation (1997), Am. J. Respir. Cell Mol. Biol., 16, 489-494.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
211000
-
deduced from nucleotide sequence Homo sapiens
214000
-
1 * 214000, SDS-PAGE, endothelial enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Homo sapiens phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability ADP + phosphorylated myosin light chain
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Homo sapiens Q15746
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
Homo sapiens
-
endothelium
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability Homo sapiens ADP + phosphorylated myosin light chain
-
?

Subunits

Subunits Comment Organism
monomer
-
Bos taurus
monomer 1 * 214000, SDS-PAGE, endothelial enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
MLCK
-
Homo sapiens
myosin light chain kinase
-
Homo sapiens